Download PDF
Synfacts 2008(12): 1302-1302  
DOI: 10.1055/s-0028-1083618
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Michael Addition of Nitroalkanes to Nitroolefins

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
X. Yang, X. Zhou, L. Lin, L. Chang, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
Further Information

Publication History

Publication Date:
20 November 2008 (online)

    Permissions and Reprints

Significance

1,3-Dinitro compounds represent an important class of precursors to a wide range of versatile building blocks including those used in the synthesis of pharmaceuticals. Additionally, the nitro moiety can be reduced to provide 1,3-amino products which are used in a large number of chiral ligands for asymmetric catalysis. This paper presents a lanthanum catalyst, which provides 1,3-dinitro compounds in high efficiency, enantio- and diastereoselectivity.