Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2008(12): 1310-1310
DOI: 10.1055/s-0028-1083621
DOI: 10.1055/s-0028-1083621
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel P-O-P Ligands for Highly Efficient Hydrogenation of Alkenes
H. Fernández-Pérez, M. A. Pericàs, A. Vidal-Ferran*
Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Universitat de Barcelona and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Significance
In this account, the preparation and application of a library of novel P-O-P ligands for asymmetric hydrogenation is described. Various phosphine-phosphinite and phosphine-phosphite ligands were easily prepared from enantiopure Sharpless epoxy ethers. While several provide moderate levels of enantioselectivity and/or reactivity, ligand 1 was found to be highly efficient for the hydrogenation of different alkenes.