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Synfacts 2009(1): 0070-0070
DOI: 10.1055/s-0028-1087281
DOI: 10.1055/s-0028-1087281
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed Counteranion-Induced Asymmetric Hydrogenation of Imines
C. Li, C. Wang, B. Villa-Marcos, J. Xiao*
The University of Liverpool, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Dezember 2008 (online)
Significance
An Ir-catalyzed asymmetric hydrogenation of acyclic imines is described. Several of the substrates examined have been reported to give lower enantioselectivities under different hydrogenation conditions (S. Hoffmann, A. M. Seayad, B. List Angew. Chem. Int. Ed. 2005, 44, 7424). A chiral phosphate counteranion is used for enantioselective induction. Excellent yields and enantioselectivities are seen for a broad range of N-aryl imines.