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Synfacts 2008(12): 1253-1253  
DOI: 10.1055/s-0028-1087284
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Quinocarcin

Contributor(s): Philip Kocienski, Stewart Eccles
Y.-C. Wu, M. Liron, J. Zhu*
Institut de Chemie des Substances Naturelles, Gif-sur-Yvette, France
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Quinocarcin was isolated from the culture broth of Streptomyces melunovinuceus. It shows good antitumor activity against a range of cancer cell lines. The cytotoxicity of quinocarcin is caused by autoredox disproportionation of the ­oxazolidine, which reduces molecular oxygen to superoxide and causes oxidative damage to DNA.