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Synfacts 2008(12): 1241-1241  
DOI: 10.1055/s-0028-1087293
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Actinophyllic Acid

Contributor(s): Philip Kocienski, Stewart Eccles
C. L. Martin, L. E. Overman*, J. M. Rohde
University of California, Irvine, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

()-Actinophyllic acid was isolated from the leaves of the tree Alstonia actinophylla. It is an inhibitor of carboxypeptidase U, an endogenous inhibitor of the process the body uses to clear fibrin clots. This synthesis proceeds in only eight stages all but one of which construct C-C or C-N bonds.