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Synfacts 2008(12): 1247-1247
DOI: 10.1055/s-0028-1087295
DOI: 10.1055/s-0028-1087295
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (-)-Secu’amamine
P. Liu, S. Hong, S. M. Weinreb*
The Pennsylvania State University, University Park, USA
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Significance
Secu’amamine is isolated from the Securinega and Phyllanthus plants. Members of the family show antimalarial and antibacterial activity and they have been used in the clinic for treatment of poliomyelitis and chronic aplastic anemia. This first total synthesis of secu’amamine forms the tetracyclic skeleton by a conjugate addition-intramolecular aldol addition-lactonization pathway.