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Synfacts 2008(12): 1303-1303
DOI: 10.1055/s-0028-1087320
DOI: 10.1055/s-0028-1087320
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Air-Stable Iridium Catalyst in Asymmetric Allylic Substitution
S. Spiess, C. Welter, G. Franck, J.-P. Taquet, G. Helmchen*
Ruprecht-Karls-UniversitÄt Heidelberg, Germany
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Significance
The authors report a new iridium catalyst system for the asymmetric allylic substitution reaction, furnishing improved chemoselectivity and comparable yields without the need for inert atmosphere. Additional mechanistic insight into precatalyst formation is reported based on ³¹P NMR experiments.