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Synfacts 2009(1): 0082-0082  
DOI: 10.1055/s-0028-1087455
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Trichlorosilane-Mediated Conjugate Reduction and Reductive Aldol Reaction

Contributor(s): Paul Knochel, Tobias Thaler
M. Sugiura*, N. Sato, S. Kotani, M. Nakajima*
Kumamoto University, Japan
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Publikationsverlauf

Publikationsdatum:
18. Dezember 2008 (online)

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Significance

Both conjugate reduction and ­reductive aldol reactions on α,β-unsaturated ­ketones were successfully carried out using trichlorosilane in combination with a Lewis base. The trichlorosilane-mediated reduction of the ­ketone proceeds selectively leading to the 1,4-reduction product.