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Synfacts 2009(2): 0215-0215  
DOI: 10.1055/s-0028-1087592
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Active Catalyst for the Addition of Indoles to Nitroalkenes

Contributor(s): Benjamin List, Ilija Èorić
M. Ganesh, D. Seidel*
The State University of New Jersey, Piscataway, USA
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Publikationsverlauf

Publikationsdatum:
22. Januar 2009 (online)

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Significance

Active catalysts for the addition of indoles to nitroalkenes have been developed. Quinolinium thioamide catalyst 1 gave products in high yields and excellent enantioselectivities. Comparison with thiourea-based catalyst 2 ­reveals a 280-fold effective rate acceleration achieved using catalyst 1, as well as a much ­higher enantioselectivity.