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Synfacts 2009(2): 0122-0122  
DOI: 10.1055/s-0028-1087606
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of (-)-Platencin

Contributor(s): Philip Kocienski, Stewart Eccles
K. Tiefenbacher*, J. Mulzer*
Universität Wien, Austria
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Publication History

Publication Date:
22 January 2009 (online)

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Significance

Platencin was isolated from the ­microorganism Streptomyces platensis along with platensimycin. Both natural products have sparked a great deal of interest due to their impressive antibiotic properties, especially against drug resistant bacterial strains. This paper details a short and simple route to the polycyclic head of platencin.