Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(2): 0179-0179
DOI: 10.1055/s-0028-1087632
DOI: 10.1055/s-0028-1087632
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Mannich Reaction of Glycinate Schiff Bases with Imines
J. Hernández-Toribio, R. G. Arrayás*, J. C. Carretero*
Universidad Autónoma de Madrid, Spain
Further Information
Publication History
Publication Date:
22 January 2009 (online)
Significance
The authors report the synthesis of anti-α,β-diamino esters using a copper-catalyzed Mannich reaction between glycine Schiff bases and 8-quinolyl-protected sulfonylimines. The reaction was also successful for alanine Schiff bases. The deprotection of the 8-quinolyl group on the sulfonylimine can be accomplished by using a large excess of magnesium.