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Synfacts 2009(2): 0175-0175
DOI: 10.1055/s-0028-1087636
DOI: 10.1055/s-0028-1087636
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Bimetallic Palladium Catalyzed Michael Addition of α-Cyanoacetates
S. Jautze, R. Peters*
ETH Zürich, Switzerland and Universität Stuttgart, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Januar 2009 (online)
Significance
The authors report the use of a bimetallic palladium catalyst in the addition of α-cyanoacetates to enones, giving products in high yields and enantioselectivity. α-Cyanoacetates have comprised a difficult nucleophile for conjugate addition, with most published examples reporting either limited scope or enantioselectivity.
Book: Multimetallic Catalysts in Organic Synthesis M. Shibasaki; Y. Yamamoto, Eds.; Wiley-VCH: Weinheim, 2004.