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Synfacts 2009(2): 0173-0173  
DOI: 10.1055/s-0028-1087637
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Enantioselective Multicomponent Reaction

Contributor(s): Mark Lautens, Jane Panteleev
X. Xu, J. Zhou, L. Yang, W. Hu*
East China Normal University, Shanghai, P. R. of China
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Publikationsverlauf

Publikationsdatum:
22. Januar 2009 (online)

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Significance

Ongoing interest in multicomponent reactions (MCRs) has been fueled by their ability to generate complex products from simple precursors through a modular approach. Complementing the group’s previous work (J. Am. Chem. Soc. 2008, 130, 7782), the authors report a four-component MCR accessing β-amino-α-hydroxy-esters 5, in variable yield and good enantioselectivity.

Book: Multicomponent Reactions, J. Zhu, H. Bienaymé, Eds.; Wiley-VCH: Weinheim, 2005.