RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2009(2): 0185-0185
DOI: 10.1055/s-0028-1087643
DOI: 10.1055/s-0028-1087643
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Quaternary Center Formation via Diastereoselective Arylation of Enolates
E. A. Bercot*, S. Caille*, T. M. Bostick, K. Ranganathan, R. Jensen, M. M. Faul
Amgen Inc., Thousand Oaks, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Januar 2009 (online)
Significance
The construction of all-carbon quaternary centers is the challenge addressed using a commercial catalyst in a simple procedure. Impressively, the reaction allows the arylation of enolates where diastereoselectivity is controlled by a remote group. Various aryl and alkenyl bromides can be added to cyclohexyl enolates with synthetically useful stereoselectivity. Complex functionalized cyclohexyl derivatives can be prepared from simple reagents.