Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(2): 0193-0193
DOI: 10.1055/s-0028-1087647
DOI: 10.1055/s-0028-1087647
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Ta(V)-Catalyzed Hydroaminoalkylation of Olefins with Dialkylamines
S. B. Herzon, J. F. Hartwig*
University of Illinois, Urbana, USA
Further Information
Publication History
Publication Date:
22 January 2009 (online)
Significance
A direct addition of an amine to non-activated alkenes is an unusual and rare, although highly desirable reaction. Chlorotantalum amide complexes catalyze the hydroaminoalkylation of simple terminal alkenes by secondary dialkylamines with high efficiency, providing the branched addition products in excellent yields and selectivities. This is an important step in the development of general methodology of catalytic amination of alkenes, the process of potentially great importance for chemical industry.