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Synfacts 2009(2): 0189-0189  
DOI: 10.1055/s-0028-1087658
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mn-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Alkenyl Halides

Contributor(s): Paul Knochel, Tobias Thaler
G. Cahiez*, O. Gager, F. Lecomte
Université de Paris13, Bobigny, France
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Publikationsdatum:
22. Januar 2009 (online)

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Significance

In this article a highly stereoselective Mn(II)-catalyzed cross-coupling reaction between (hetero)aryl Grignard reagents and non-­activated alkenyl halides is reported. The stereo­information of the alkenyl halide is usually preserved. An exception to that rule represents the case of (Z)-3-(2-bromoethenyl)pyridine, where the configuration of the double bond is completely ­reversed.