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Synfacts 2009(5): 0474-0474
DOI: 10.1055/s-0028-1088166
DOI: 10.1055/s-0028-1088166
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Amphidinolides B1 and B2
L. Lu, W. Zhang, R. G. Carter*
Oregon State University, Corvallis, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
Amphidinolides B1 and B2 possess cytotoxic activity against certain cancer lines. This first total synthesis of amphidinolides B1 and B2 focuses on the aldol condensation of fragments F and G. For a correction to the article see: J. Am. Chem. Soc. 2008, 130, 11834.