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Synfacts 2009(7): 0709-0709  
DOI: 10.1055/s-0029-1217240
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Caulerpenynol

Contributor(s): Philip Kocienski
L. Commeiras*, J. Thibonnet, J.-L. Parrain*
Aix-Marseille Université, France
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Publikationsdatum:
22. Juni 2009 (online)

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Significance

Caulerpenynol, a metabolite of the green tropical seaweed Caulerpa taxifolia, has ­antibacterial and cytotoxic properties. This first synthesis is based on the diastereoselective addition of the alkenyllithium E to the aldehyde D. The resultant adducts are separable by column chromatography.