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Synfacts 2009(8): 0869-0869
DOI: 10.1055/s-0029-1217417
DOI: 10.1055/s-0029-1217417
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper/Aminohydroxyphosphine-Catalyzed Allylic Substitution of Cinnamyl Phosphates
N. Yoshikai, K. Miura, E. Nakamura*
The University of Tokyo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Juli 2009 (online)
Significance
The copper/aminohydroxyphosphine-catalyzed enantioselective SN2-type allylic substitution reaction of cinnamyl phosphates is developed. By optimizing the copper source, solvent and other reaction conditions good yields and excellent ee values are obtained. The proposed reaction mechanism is supported by computational studies.