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Synfacts 2009(8): 0879-0879  
DOI: 10.1055/s-0029-1217434
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cocatalyzed Asymmetric Reductive Amination

Contributor(s): Mark Lautens, Jacki Kitching
C. Li, B. Villa-Marcos, J. Xiao*
University of Liverpool, UK
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

As an extension on previous work involving the asymmetric hydrogenation of imines (J. Am. Chem. Soc. 2008, 130, 13208; J. Am. Chem. Soc. 2008, 130, 14450), the authors now describe a protocol for the direct asymmetric reductive amination (DARA) of prochiral ketones. Using this metal-Brønsted acid cooperative catalysis procedure, the target amines are obtained in excellent yield and enantioselectivity.