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Synfacts 2009(8): 0852-0852  
DOI: 10.1055/s-0029-1217467
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

BODIPY-Based Nitrite Detection

Contributor(s): Timothy M. Swager, Mindy Levine
Z.-N. Sun, H.-L. Wang, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*
The University of Hong Kong, P. R. of China
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Publikationsdatum:
23. Juli 2009 (online)

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Significance

Overexpression of peroxynitrite in vivo is linked to many human diseases. Selective and sensitive in vivo detection of peroxynitrite is therefore highly desirable. This article reports the use of BODIPY-based fluorophore 3 to selectively detect peroxynitrite in vivo compared to other reactive oxygen and nitrogen species.