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Synfacts 2009(8): 0901-0901  
DOI: 10.1055/s-0029-1217481
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

An NHC-Ligated Palladacycle as an Active Catalyst for Heck-Mizoroki Reaction

Contributor(s): Paul Knochel, Andrei Gavryushin
G.-R. Peh, E. A. B. Kantchev*, C. Zhang, J. Y. Ying*
Institute of Bioengineering and Nanotechnology, The Nanos, Singapore
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

This new catalyst mediates the Heck-Mizoroki reaction of aryl and hetaryl bromides at 0.1-2 mol% range without the need of anhydrous techniques or exclusion of air. It can be readily prepared in one step on a 100 g scale. TONs of up to 5˙105 were achieved for some substrates. Bis-arylated alkenes can also be obtained from electron-rich aromatic compounds.