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Synfacts 2009(8): 0897-0897  
DOI: 10.1055/s-0029-1217484
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu(I)-Catalyzed Diamination of Disubstituted Terminal Alkenes

Contributor(s): Paul Knochel, Andrei Gavryushin
Y. Wen, B. Zhao, Y. Shi*
Colorado State University, Fort Collins, USA
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Publikationsverlauf

Publikationsdatum:
23. Juli 2009 (online)

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Significance

Vicinal diamines are important functional moieties in biologically active molecules. This method of olefin diamination offers a simple synthetic route towards many highly pharmacologically interesting structures. tert-Butyl groups can be readily and selectively cleaved in the products in a strong acidic media. Several important functional groups are well tolerated in this reaction.