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Synfacts 2009(8): 0928-0928  
DOI: 10.1055/s-0029-1217495
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Traceless Synthesis of N-Unsubstituted Pyrazoles on a Solid Support

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Elisabetta Greco
K. Harju, J. Vesterinen, J. Yli-Kauhaluoma*
University of Helsinki, Finland
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Publikationsdatum:
23. Juli 2009 (online)

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Significance

A solid-phase synthesis of pharmacological active pyrazole compounds has been described. The novel synthetic method proceeds via sydnone’s formation in a microwave reactor in order to act as azomethine imine-type dipoles. A 2-methoxybenzyl resin has been employed for this purpose and was easily cleaved from the desired pyrazoles in acidic conditions.