C-C Cross-Coupling of Alcohols Catalyzed by Ag/Al₂O₃

Significance

γ-Alumina-supported silver clusters (Ag/Al₂O₃) catalyzed the C-C bond formation of secondary alcohols 1 and primary alcohols 2 in the presence of Cs₂CO₃ to give the corresponding ketones 3 in 51-81% yield (12 examples). The catalyst was recovered by filtration and reused twice without significant loss of activity after the reactivation (e.g., formation of 3a; 1^st reuse: 77%, 2^nd reuse: 78%).