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Synfacts 2009(8): 0822-0822
DOI: 10.1055/s-0029-1217505
DOI: 10.1055/s-0029-1217505
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of ()-Anthecularin
Y. Li, C. C. Nawrat, G. Pattenden*, J. M. Winne
University of Nottingham, UK
Further Information
Publication History
Publication Date:
23 July 2009 (online)
Significance
Anthecularin inhibits two key enzymes in the plasmodium fatty acid synthase complex and hence possesses weak antimalarial activity. The key step in the synthesis depicted is an intramolecular 1,3-dipolar cycloaddition of the oxidopyrylium ion I.