Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(8): 0828-0828
DOI: 10.1055/s-0029-1217509
DOI: 10.1055/s-0029-1217509
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Dysibetaine
J. Isaacson, Y. Kobayashi*
University of California, San Diego, La Jolla, USA
Further Information
Publication History
Publication Date:
23 July 2009 (online)
Significance
(-)-Dysibetaine was isolated from the Micronesian sponge Dysidea herbacea. The compound exhibits potential neuroexcitotoxin activity. The featured step of the synthesis is the 4-center/3-component Ugi reaction (A → F). For a synthesis of racemic dysibetaine using a simillar approach, see: Y. Kobayashi and co-workers Org. Lett. 2008, 10, 1461.