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Synfacts 2009(8): 0818-0818
DOI: 10.1055/s-0029-1217573
DOI: 10.1055/s-0029-1217573
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of a Hepatitis C Polymerase Inhibitor
H. Li et al.*
Pfizer Global Research and Development, La Jolla, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Juli 2009 (online)
Significance
Hepatitis C virus infects over 3% of the world population and is one of the leading causes of chronic liver diseases. The target molecule is a potent and selective inhibitor of HCV polymerase, an enzyme that plays a vital role in virus replication, and has entered human clinical trials in patients infected with genotype 1 hepatitis C virus.