PDF herunterladen
Synfacts 2009(8): 0826-0826  
DOI: 10.1055/s-0029-1217577
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Phorbasin C

Contributor(s): Philip Kocienski, Indu Dager
T. K. Macklin, G. C. Micalizio*
Yale University, New Haven, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. Juli 2009 (online)

    Lizenzen und Reprints

Significance

Members of the phorbasin class of diterpenes inhibit Gram positive bacteria like Staphylococcus aureus and Micrococcus luteuss. This first total synthesis of (+)-phorbasin C uses an allylic alcohol-alkyne reductive cross-coupling reaction a a key step and also determines the correct stereochemistry of the molecule.