PDF herunterladen
Synfacts 2009(8): 0819-0819  
DOI: 10.1055/s-0029-1217580
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Subglutinol A

Contributor(s): Philip Kocienski
H. Kim, J. B. Baker, S.-U. Lee, Y. Park, K. L. Bolduc, H.-B. Park, M. G. Dickens, D.-S. Lee, Y. Kim, S. H. Kim*, J. Hong*
Duke University, Durham, USA; Korea Research Institute of Chemical Technology and Chungnam National University, Daejon, Seoul National University, and Gwangju Institute of Science & Technology, Korea
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. Juli 2009 (online)

    Lizenzen und Reprints

Significance

Subglutinol A, a non-toxic metabolite of the fungus Fusarium subglutinans, displays immunosuppressive activity (IC50 = 25 nM, MLR assay) and some osteogenic (i.e. bone-forming) efficacy, unlike the immunosuppressants cyclo-sporin and FK-506 which can cause osteoporosis.