Synthesis of a Polychlorinated Sulpholipid Cytotoxin

Significance

The polychlorinated sulpholipid K is a shellfish poison extracted from the digestive glands of contaminated mussels. It is probably a metabolite of microalgae ingested by the mussels and concentrated in their gut. Carreira and co-workers report the first diastereoselective synthesis of a polychlorinated sulpholipid which also confirms the assigned stereochemistry.