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Synfacts 2009(11): 1194-1194  
DOI: 10.1055/s-0029-1218028
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-Hopeanol

Contributor(s): Philip Kocienski, Zofia Komsta
K. C. Nicolaou*, T. R. Wu, Q. Kang, D. Y.-K. Chen*
The Scripps Research Institute, La Jolla, University of California, San Diego, La Jolla, USA and Agency for Science, Technology and Research (A*STAR), Singapore
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

Hopeanol, isolated from Hopea exalata, is cytotoxic against a variety of tumor cells. Hopeanol is believed to be the biosynthetic precursor to hopeahainol A, which is a micromolar inhibitor of acetylcholinesterase (its synthesis is also presented in the article, one step from F). The ­series of quite efficient cascade reactions led to racemic hopeanol in good yield.