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Synfacts 2009(11): 1185-1185
DOI: 10.1055/s-0029-1218033
DOI: 10.1055/s-0029-1218033
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Oseltamivir
B. Sullivan, I. Carrera, M. Drouin, T. Hudlicky*
Brock University, St. Catharines, Canada and Universidad de la República, Montevideo, Uruguay
Further Information
Publication History
Publication Date:
22 October 2009 (online)
![](https://www.thieme-connect.de/media/synfacts/200911/lookinside/thumbnails/10.1055-s-0029-1218033-1.jpg)
Significance
Oseltamvir (Tamiflu) is the prime drug for the treatment of avian H1N1 influenza. Syntheses of oseltamivir starting with enzymatic dihydroxylation of bromobenzene were reported in 2008 by the groups of Hudlicky, Fang, and Banwell. By starting with ethyl benzoate, the synthesis depicted avoids a palladium-catalyzed carbonylation to install the ester function.