Pd-Catalyzed Decarboxylative Arylation of C-H Bonds

Significance

An efficient protocol for the ortho-selective C-H arylation using aryl acylperoxides as aryl sources was developed. This decarboxylative arene C-H arylation reaction is supposed to proceed via directing-group-assisted cyclopalladation and subsequent reaction of the resulting palladacycle with the aryl radicals generated in situ from thermal decomposition of the peroxides. ­Pyridyl, oxime and oxazoline moieties were hereby used as directing groups. Bromo, cyano, aldehyde and nitro groups are well tolerated under the reaction conditions.