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Synfacts 2009(11): 1261-1261  
DOI: 10.1055/s-0029-1218044
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Fe-Catalyzed Oxidative Cyanation of Tertiary Amines

Contributor(s): Paul Knochel, Andreas J. Wagner
W. Han, A. R. Ofial*
Ludwig-Maximilians-Universität München, Germany
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Publikationsverlauf

Publikationsdatum:
22. Oktober 2009 (online)

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Significance

The authors demonstrate that environmentally benign iron salts efficiently activate C(sp³)-H bonds next to a tertiary amine nitrogen atom, therefore enabling cross-coupling reactions with cyanide at room temperature in the presence of tert-butyl hydroperoxide. The resulting α-cyano amines are obtained in high yields.