Download PDF
Synfacts 2009(11): 1242-1242  
DOI: 10.1055/s-0029-1218082
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Asymmetric Conjugate Boration of Cyclic Enones

Contributor(s): Hisashi Yamamoto, Zhi Li
I-H. Chen, L. Yin, W. Itano, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information

Publication History

Publication Date:
22 October 2009 (online)

    Permissions and Reprints

Significance

Highly enantioenriched tertiary organoboronic esters are obtained from copper-catalyzed conjugate boration reactions. The catalyst system consists of CuPF6(MeCN)4, the chiral ­QuinoxP* ligand and lithium tert-butoxide. The authors rationalized that a catalytic amount of LiPF6 was generated in the reaction that accelerates the catalytic cycle, therefore lithium salt is essential to this reaction.