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Synfacts 2009(11): 1245-1245
DOI: 10.1055/s-0029-1218125
DOI: 10.1055/s-0029-1218125
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Chiral Mn(II) Complexes for Asymmetric Epoxidation of Olefins
M. Wu, B. Wang, S. Wang, C. Xia*, W. Sun*
Lanzhou Institute of Chemical Physics and Graduate School of the Chinese Academy of Sciences, Beijing, P. R. Of China
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
The asymmetric epoxidation of olefins is one of the most studied reactions due to the high synthetic value of the resulting enantiopure epoxides. The authors report the development of a novel family of chiral Mn(II) complexes of N4-ligands for the asymmetric epoxidation of enones and nonfunctionalized olefins, with H2O2 in the presence of acetic acid. With 1 mol% catalyst loading, the enantioselective epoxidation of olefins proceeds with good yields and up to 89% ee.