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Synfacts 2009(12): 1384-1384  
DOI: 10.1055/s-0029-1218168
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cross-Coupling of Organozinc Reagents with Thiomethylated Heterocycles

Contributor(s): Paul Knochel, Andrei Gavryushin
A. Metzger, L. Melzig, C. Despotopoulou, P. Knochel*
Ludwig-Maximilians-Universität, München, Germany
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

A broad number of thiomethyl-substituted heterocycles like pyridines, pyrimidines, triazines, pyrazoles, quinazolines, etc. can be coupled at room temperature with readily available functionalized aryl-, heteroaryl-, benzyl- and alkyl-zinc compounds in the presence of a Pd/S-Phos catalytic system. This is an excellent method for the preparation of polysubstituted heterocycles.