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Synfacts 2009(12): 1393-1393  
DOI: 10.1055/s-0029-1218171
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

(NHC)-Pd or -Ni-Catalyzed Oxidation of Secondary Alcohols by Chlorobenzene

Contributor(s): Paul Knochel, Andrei Gavryushin
C. Berini, D. F. Brayton, C. Mocka, O. Navarro*
University of Hawaii at Manoa, Honolulu, USA
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

The authors demonstrated the use of commercial Pd- and Ni-NHC complexes as catalysts for performing a mild and selective anaerobic oxidation of secondary alcohols into ­ketones with chlorobenzene as an oxidant. The reaction can be carried out at room temperature. For the first time, the use of an inexpensive nickel catalyst is described for this useful synthetic transformation.