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Synfacts 2009(12): 1389-1389  
DOI: 10.1055/s-0029-1218173
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ni-Catalyzed Arylation of Arylzinc Reagents with N-Aromatic Heterocycles

Contributor(s): Paul Knochel, Andreas J. Wagner
M. Tobisu*, I. Hyodo, N. Chatani*
Osaka University, Japan
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

A regioselective C-H bond arylation at the C2 position of electron-deficient hetero­arenes, such as quinolines, isoquinolines, or ­pyridines, is achieved using Ni(cod)2/Cy3P as ­catalyst. Several functionalities such as methoxy, dimethylamino, or chloro substituents are tolerated.