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Synfacts 2009(12): 1391-1391
DOI: 10.1055/s-0029-1218174
DOI: 10.1055/s-0029-1218174
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Allylic Ethers as Educts for Aqueous Suzuki-Miyaura Couplings
T. Nishikata, B. H. Lipshutz*
University of California, Santa Barbara, USA
Further Information
Publication History
Publication Date:
20 November 2009 (online)
Significance
The first palladium-catalyzed Suzuki-Miyaura cross-coupling of functionalized allylic ethers is disclosed. It is conducted in water as the only medium and made possible by micellar catalysis by the non-ionic amphiphile PTS. Among a variety of screened ligands, DPEPhos turned out to be most efficient.