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Synfacts 2009(12): 1397-1397
DOI: 10.1055/s-0029-1218208
DOI: 10.1055/s-0029-1218208
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Direct Hydroxymethylation Using Formaldehyde
R. K. Boeckmann Jr.*, J. R. Miller
University of Rochester, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2009 (online)
Significance
A practical amine 1 catalyzed asymmetric hydroxymethylation of aldehydes with formaldehyde is reported. Further reaction of the desired hydroxyaldehyde resulted in its hemiacetal equivalent 2 as the product, incorporating a second equivalent of formaldehyde. Due to the instability, this species was transformed into the corresponding carboxylic acids 3 or the protected alcohols 4, respectively.