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Synfacts 2009(12): 1306-1306  
DOI: 10.1055/s-0029-1218324
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a CETP Inhibitor

Contributor(s): Philip Kocienski
T. A. Rano*, G.-H. Kuo
Johnson & Johnson Pharmaceutical Research and Development, Raritan, USA
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Publikationsdatum:
20. November 2009 (online)

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Significance

Inhibition of cholesteryl ester transfer protein (CETP) leads to elevation of plasma high density lipoprotein cholesterol (”good" cholesterol) and lowering of plasma low density lipoprotein cholesterol (”bad" cholesterol) with an ­ensuing beneficial plasma lipid profile.