Synthesis of (-)-Himandrine

M. Movassaghi; M. Tjandra; J. Qi

doi:10.1055/s-0029-1218327

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Synfacts 2009(12): 1305-1305
DOI: 10.1055/s-0029-1218327

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Himandrine

Contributor(s): Philip Kocienski
M. Movassaghi*, M. Tjandra, J. Qi
Massachusetts Institute of Technology, Cambridge, USA

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Publication History

Publication Date:
20 November 2009 (online)

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Significance

(-)-Himandrine was isolated from the bark of the tree Galbulimima belgraveana. Eight of the ten stereogenic centers were created by diastereoselective processes starting from just two stereogenic centers in fragments B and H.