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Synfacts 2010(1): 0096-0096  
DOI: 10.1055/s-0029-1218431
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple Cu-Catalyzed Synthesis of Phenols from Aryl Halides

Contributor(s): Paul Knochel, Andrei Gavryushin
A. Tlili, N. Xia, F. Monnier, M. Taillefer*
Institut Charles Gerhardt Montpellier, France
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

The authors report an inexpensive copper-catalyzed system for direct hydroxylation of aryl halides (iodides and bromides) using an ­alkali metal base as the nucleophile. The reaction tolerates a broad number of functional groups and proceeds at relatively low temperature (110-120 ˚C). Aryl bromides react smoothly in the presence of sodium iodide.