Palladium-Catalyzed Newman-Kwart Rearrangement of
Thiocarbamates

J. N. Harvey; J. Jover; G. C. Lloyd-Jones; J. D. Moseley; P. Murray; J. S. Renny

doi:10.1055/s-0029-1218432

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Synfacts 2010(1): 0087-0087
DOI: 10.1055/s-0029-1218432

Metal-Mediated Synthesis

Palladium-Catalyzed Newman-Kwart Rearrangement of Thiocarbamates

Contributor(s): Paul Knochel, Andreas J. Wagner
J. N. Harvey, J. Jover, G. C. Lloyd-Jones*, J. D. Moseley, P. Murray, J. S. Renny
University of Bristol and AstraZeneca, Bristol, UK

Further Information

Publication History

Publication Date:
21 December 2009 (online)

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Significance

This new procedure for the thermally induced O-S migration in aryl thiocarbamates (referred to as the Newman-Kwart rearrangement) uses Pd(Pt-Bu₃)₂ as catalyst, thereby significantly reducing the required reaction temperatures.