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Synfacts 2010(1): 0117-0117  
DOI: 10.1055/s-0029-1218448
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Silica-Alumina-Supported Catalysts for Efficient 1,4-Addition Reactions

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
K. Motokura, S. Tanaka, M. Tada, Y. Iwasawa*
The University of Tokyo, Tokyo Institute of Technology, Yokohama, Institute for Molecular Science, Okazaki, and The University of Electro-Communications, Tokyo, Japan
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Publikationsdatum:
21. Dezember 2009 (online)

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Significance

Silica-alumina-supported tertiary amine catalysts [e.g., SA(500)-NEt2 (‘500’ was denoted as calcination temperature (˚C)] were applied to 1,4-addition of nitroalkanes and thiols to eletron-deficient alkenes. The 1,4-addition of nitroalkanes 1 (3 mmol) to alkenes 2 (1 mmol) was carried out with the SA(500)-NEt2 (0.045 mmol) in toluene to give the corresponding products 3 (11 examples, 24-96% yield).