Rhodium-Catalyzed β-Boration of α,β-Unsaturated Carbonyl Compounds

Significance

The introduction of boronate esters β to carbonyls cannot be achieved by classical asymmetric hydroboration. Metal-catalyzed addition of boron reagents to α,β-unsaturated carbonyl compounds has become a reliable method to introduce this functionality. In this report, the authors utilize their previously developed chiral rhodium(III) catalysts to achieve asymmetric conjugate addition of a diboron reagent to obtain enantio­enriched β-boryl carbonyl derivatives.