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Synfacts 2010(1): 0070-0070
DOI: 10.1055/s-0029-1218503
DOI: 10.1055/s-0029-1218503
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Conjugate Alkynylation with TMS-acetylene
E. Fillion*, A. K. Zorzitto
University of Waterloo, Canada
Further Information
Publication History
Publication Date:
21 December 2009 (online)
Significance
The authors utilized TMS-acetylene for the rhodium/diphosphine complex catalyzed conjugate addition of 5-benzylidene Meldrum’s acids, which are believed to be highly electrophilic acceptors. Similar reactions were previously reported to proceed with phenylacetylene or (triisopropylsilyl)acetylene as nucleophiles.