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Synfacts 2010(3): 0271-0271  
DOI: 10.1055/s-0029-1219248
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Syntheses of (±)-Poitediol and (-)-Teucladiol

Contributor(s): Steven V. Ley, David J. France
M. S. Dowling, C. D. Vanderwal*
University of California, Irvine, USA
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

A novel strategy for the synthesis of contra-thermodynamic exocyclic alkenes is described in the context of the syntheses of poitediol and teucladiol. The approach relies on RCM and subsequent SE′ elimination of an allylsilane.